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KMID : 0351619740150020155
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Kyungpook Medical Journal
1974 Volume.15 No. 2 p.155 ~ p.164
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Signigicance of Abnormal Serum Ceruloplasmin in Hepatobiliary Disorder
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Abstract
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The present study was undertaken to determine whether knowledge of serum ceruloplasmin might aid in the differential diagnosis of hepatobiliary disease, to delineate factors that regulate the level of ceruloplasmin in the serum by correlation with other biochemical findings.
In 32 healthy male, the mean velue for serum ceruloplasmin was 27.5±5.2mg/100m1. The serum ceruloplasmin concentration in 26 patients with acute hepatitis, 33 with liver cirrhosis 13 with hepatoma and 10 with extrahepatic obstruction were 53.0±12.0, 43.8±19.3, 67.3±17.2 and 74.5±1.5 respectively.
In acute hepatitis, significant cerrelation was found with total bilirubin (r=0.442, P<0.05) and alkaline phosphatase (r=0.442, P<0.05). The correlations with SGOT(r=0.282) and SGPT (r=0.239) were statistically not significant.
In the group of liver cirrhosis, no significant correlation was observed with albumin (r=0.166) and r-globulin (r=-0.052), but a positive correlation was found with α₂-globulin (r=0.415, P<0.05)
In hepatoma, significant correlation was found with alkaline phosphatase. (r=0.659, P<0.05). In extrahepatic obstruction, all of 10 patients had elevated ceruloplasmin values. However, the correlations with total bilirubin (r=0.158) and alkaline phosphatase (r=0.315) were statistically not significant.
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KEYWORD
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